What is (HA)?
|HA is a high molecular weight polysaccharide composed of alternating molecules of N-acetyl glucosamine and D-glucuronic acid. It is a member of the glycosaminoglycan family that is found within collagen throughout the body. Unlike other types of connective tissue HA is not linked to other proteins or sulfur.
As the most important space filling substance in the human body HA holds more water than any other molecule in the body and is necessary to keep collagen hydrated and youthful.
What does HA do in the body?
HA supports the structure of connective tissue by acting as a water magnet to maintain extracellular fluidity. HA forms a viscous fluid with exceptional lubricating properties necessary for the vital functions of many parts of the human body including the skin, heart valves, aqueous/ vitreous humor of the eye and synovial fluid (joint lubricant). The skin contains over 50% of the bodies HA. Considering that skin is over 70% water and renews itself more readily than most other bodily tissues HA is absolutely vital for it's structure and daily maintenance. It's constantly involved in cellular renewal and repair because of daily exposure to solar radiation, pressure, heat, trauma and wound healing.
What is HA made from?
HA is made by human fibroblast cells. Commercial sources may be from Cocks combs, Chicken cartilage or Microbial fermentation. NOW Foods is a vegetarian source made via Microbial fermentation.
How much HA should I take?
Our bodies are in a continual state of rebuilding. New skin cells for example replace old ones about every 20 to 30 days. Normally, HA in skin tissue is broken down by an enzyme called Hyaluronidase at a precise rate. The rate of HA degradation can be increased by excess intake of riboflavin (B-2), ultraviolet radiation exposure and viruses. Any long-term overexposure to any of these may result in premature connective tissue destruction.
Considering that 10-150 mgs of HA is a normally metabolized or excreted daily with the higher rate of loss in persons over 50, it may make sense for older adults to begin supplementing with 1- 50mg capsule 3 times daily just to maintain equilibrium.
What is the purpose of MSM in this formula?
MSM is an organic source of sulfur, a mineral necessary for the normal function and structure of the body. Sulfur is a raw material utilized by the body to manufacture proteins, cartilage and other connective tissues. Studies with MSM have proven it to be safe and effective for the use of various types of connective tissue needs but some of its beneficial mechanisms of action are still unfolding. Radioactive labeled MSM was fed to animals at a research foundation and subsequent analyses on their serum proteins revealed that a small amount of the sulfur from the MSM had been taken up by two of the body's amino acids, methionine and cysteine.
As research continues I believe science will discover many additional reasons to include both of these safe supplements in any well designed joint, skin and hair support formula.